This course provides a comprehensive overview of Cardio-Renal-Metabolic (CRM) syndrome, focusing on the latest guideline updates and their implications for clinical practice. It highlights the importance of risk stratification and early intervention in improving patient outcomes, while exploring the interconnected nature of cardiovascular, renal, and metabolic conditions. Through interactive case discussions, the session aims to translate evidence into practical management strategies, supporting clinicians in delivering integrated, patient-centered care.