This session focuses on optimizing acute migraine management through early, targeted intervention, emphasizing the principle of “start early, get it right” to improve treatment outcomes and prevent chronification. It reviews the clinical features of migraine and the importance of timely therapy, highlighting first-line treatments such as NSAIDs and triptans, as well as newer options including gepants and ditans for specific patient populations. The role of non-oral formulations in managing severe symptoms is also addressed. Emphasis is placed on patient education, personalized treatment strategies, and stratified care models to align therapy with attack severity and individual needs. Overall, the session aims to enhance clinical practice by reducing disability, improving patient satisfaction, and preventing progression to chronic migraine.