Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a highly variable clinical presentation, often mimicking other common conditions and leading to diagnostic delays. Primary care physicians (PCPs) play a pivotal role in early recognition and timely referral, which can significantly reduce disease progression, organ damage, and mortality.
This talk emphasizes the importance of clinical vigilance in primary care and introduces practical tools for early identification, such as pattern recognition of multi-system symptoms and appropriate use of serologic testing. It also discusses key red flags that should prompt expedited rheumatology referral and outlines collaborative care models that improve outcomes.