This course provides a comprehensive overview of the burden of invasive meningococcal disease (IMD) and the Emirates Family Medicine Society recommendations for its prevention and management. It highlights the rapid progression, high mortality, and long-term complications associated with IMD, emphasizing the importance of early recognition in primary care. The course focuses on the identification and management of high-risk populations, including timely diagnosis, initiation of empiric therapy, and appropriate referral. It also explores preventive strategies, particularly vaccination across different age groups and risk profiles, underscoring the critical role of family physicians in risk assessment, patient education, and improving vaccination uptake to reduce disease burden.